The Relationship Between Ovarian Cancer and Depressive Symptoms: A Case Report
DOI:
https://doi.org/10.61978/medicor.v4i1.902Keywords:
Ovarian Cancer, Depressive Symptoms, Cancer Related Stress, Mental HealthAbstract
Ovarian cancer is a malignant tumor originating from the ovaries, affecting various age groups, with multiple histological types. Depression is a common mental disorder characterized by emotional and physical symptoms. Cancer diagnosis and treatment are widely recognized as major psychological stressors that can precipitate or exacerbate mental health disturbances, particularly depressive and anxiety disorders, due to the profound emotional, social, and physiological challenges experienced by patients. This case report highlights the relationship between ovarian cancer and depressive symptoms. This case report examines the relationship between ovarian cancer and depressive symptoms, with a focus on the psychological and inflammatory pathways influencing mental health. A 44-year-old woman presented with a loss of interest in activities, beginning three weeks after her ovarian cancer diagnosis. Research indicates that factors such as advanced cancer stage, poor physical functioning, and the absence or discontinuation of chemotherapy due to disease progression or treatment intolerance may increase the susceptibility to mental health disorders among ovarian cancer patients. Cancer patients, including those diagnosed with ovarian cancer, experience heightened stress and depression compared to those with non-neoplastic diseases. Depression can arise due to both psychological stress and inflammatory processes triggered by cancer treatments.
References
Arbani, R. A., Latief, K., Syahruddin, F. I., Hamsah, & Hasbi, B. E. (2023). Relationship between level of knowledge and attitude with early detection behavior of ovarian cancer at Ibnu Sina Hospital Makassar. Fakumi Medical Journal, 3(9), 660–669.
Barnard, M. E., Keller, J. P., Le, N., Antoniou, A. C., Easton, D. F., Pharoah, P. P. D., & Kelemen, L. E. (2023). Familial risk of epithelial ovarian cancer after accounting for gynaecological surgery: A population-based study. Journal of Medical Genetics, 60(2), 119–127. https://doi.org/10.1136/jmedgenet-2021-108395.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492.
Cankurtaran, I., & Halis Gunel, M. H. (2024). Fundamentals of cancer treatment service design: a guideline considering the healing environment concept. Facilities, 42(5–6), 446–471. https://doi.org/10.1108/F-12-2022-0158
Dirgayunita, A. (2016). Depresi: Ciri, Penyebab dan Penangannya. Journal An-nafs, 1(1), 1–15.
Doubeni, C. A., Doubeni, A. R., & Myers, A. E. (2016). Diagnosis and management of ovarian cancer. American Family Physician, 93(11), 937–944. https://www.aafp.org/pubs/afp/issues/2016/0601/p937.html
Endriyani, S., Lestari, R. D., Lestari, E., & Napitu, I. C. (2022). Gangguan Mental Emosional dan Depresi pada Remaja. Healthcare Nursing Journal, 4(2), 429–434.
Eng, K. H., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Dennis, J., Dunning, A. M., & Sellers, T. A. (2018). Paternal lineage early-onset hereditary ovarian cancers: A Familial Ovarian Cancer Registry study. PLoS Genetics, 14(1), 1007194. https://doi.org/10.1371/journal.pgen.1007194
Ezendam, N. P. M., Pijlman, B., Bhugwandass, C., Mols, F., Pruijt, J. F. M., & Husson, O. (2014). Chemotherapy-induced peripheral neuropathy and its impact on health-related quality of life among ovarian cancer survivors: Results from the population-based PROFILES registry. Gynecologic Oncology, 135(3), 510–517. https://doi.org/10.1016/j.ygyno.2014.09.016
Fatimah, S., Latief, S., Syahruddin, F. I., Nulanda, M., & Mokhtar, S. (2023). Faktor Risiko Penderita Kanker Ovarium di Rumah Sakit Ibnu Sina Makassar. Wal’afiat Hospital Journal, 4(1), 43–56.
Handoko, A. L., Jayadi, T., Putra, E. R. K., & Kusumosih, T. A. R. (2023). Hubungan antara obesitas dengan kanker ovarium di Rumah Sakit Bethesda Yogyakarta. Jurnal Kedokteran Meditek, 29(1), 27–33. https://doi.org/10.36452/jkmeditek.v29i1.3548.
Health, M. (2018). Health Research and Development Agency, Ministry of the Republic of Indonesia. https://repository.
Hu, S., Baraghoshi, D., Chang, C.-P., Rowe, K., Snyder, J., Deshmukh, V., Newman, M., Fraser, A., Smith, K., Peoples, A. R., Gaffney, D., & Hashibe, M. (2022). Mental health disorders in ovarian cancer survivors in a population-based cohort. National Library of Medicine, 22(2), 1801–1812.
Kamajaya, I. G. N. A. T., Brahmantara, B. N., & Wirawan, A. N. A. P. (2021). Profile of ovarian cancer patients in Mangusada Badung Regional Public Hospital. Indonesian Journal of Cancer, 15(3), 117. https://doi.org/10.33371/ijoc.v15i3.117.
Khazaei, Z., Sohrabivafa, M., Momenabadi, V., Goodarzi, E., Adineh, H. A., & Dehghani, S. L. (2021). Worldwide incidence and mortality of ovarian cancer and Human Development Index (HDI): GLOBOCAN sources and methods 2018. Journal of Preventive Medicine and Hygiene, 62(2), 174– 184. https://doi.org/10.15167/2421-4248/jpmh2021.62.2.1625.
Koswara, J. (2016). Description of depression levels in ovarian cancer patients at H. In Adam Malik General Hospital in 2016’.
Lestari, A., Budiyarti, Y., & Ilmi, B. (2020). Study Fenomenologi: Psikologis Pasien Kanker yang Menjalani Kemoterapi. Suaka Insan Nursing Journal, 5(1), 1–12.
Liu, H., & Yang, L. (2019). Dynamic changes of depression and anxiety after chemotherapy in ovarian cancer patients. National Library of Medicine, 98(31), 1–5.
Millet, B. (2024). Integrating User-Centered Design Into the Sylvester Firefighter Cancer Initiative’s Personal Exposure Reporter. Ergonomics in Design, 32(2), 19–24. https://doi.org/10.1177/10648046211051196
Momenimovahed, Z., Tiznobaik, A., Taheri, S., & Salehiniya, H. (2019). Ovarian cancer in the world: Epidemiology and risk factors. International Journal of Women’s Health, 11, 287–299. https://doi.org/10.2147/IJWH.S197604.
Nuseibeh, B. Z., Johns, S. A., Shih, P. C., Lewis, G. F., Gowan, T. M., & Jordan, E. J. (2024). Co-Designing the MOSAIC mHealth App With Breast Cancer Survivors: User-Centered Design Approach. JMIR Formative Research, 8. https://doi.org/10.2196/59426
Pitasi, O., Hildebrand, D., Liebe, R., Joyce, J., Nagykáldi, Z., Robertson, M. C., & Braun, A. (2024). Hiding in plain sight: Cooperative Extension as an underutilized approach to improving cancer survivorship outcomes in underserved populations. Journal of Cancer Survivorship. https://doi.org/10.1007/s11764-024-01687-z
Priastana, I. K. A., Agustini, I. G. A. R., & Kio, A. L. (2016). Hubungan Spiritual Well-Being dengan Tingkat Depresi Pada Lanjut Usia. Nurseline Journal, 1(2), 45–53.
Simamora, R. P. A., Hanriko, R., & Sari, R. D. P. (2018). Hubungan usia, jumlah paritas, dan usia menarche terhadap derajat histopatologi kanker ovarium di RSUD Dr. H. Abdul Moeloek Bandar Lampung tahun 2015–2016. Majority, 7(3), 7–13. https://juke.kedokteran.unila.ac.id.
Smith, H. R. (2015). Depression in cancer patients: Pathogenesis, implications, and treatment (Review. Journal of Cancer Research and Clinical Oncology, 141(9), 1509–1514.
Society, A. C. (2020). Ovarian cancer: Causes, risk factors, and prevention. https://www.cancer.org/cancer/acs-medical-content-and-news-staff.html
Suastari, N. M. P. (2017). Pemeriksaan radiologi untuk deteksi kanker payudara. Cermin Dunia Kedokteran, 45(4), 298–302. http://www.cdkjournal.com/index.php/CDK/article/view/837.
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
Tuffahati, H., Harsono, A. B., Aziz, M. A., Mantilidewi, K. I., & Erfiandi, F. (2022). Overview of clinical and histopathological characteristics. Obgynia, 5(1), 20–30.
